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GURPS Shadowrun 2050
Why? Oh, why?
Why Shadowrun? Well, I happen to like it. At least the bit around 2050 to, say, around 2058. It's a nice setting, mixing classic cyberpunk with fantasy, which offers a myriad of possibilities. This hopefully also answers the “Why 2050?” question, but there's also the fact that cyberware, etc. is still more limited in 2050, so less work to convert
Why GURPS? Similar. I like the system a lot. And it's basically built to be used for various settings. So why not?